wdormann/disable_ddeauto.reg

I've confirmed that the DDE-disabling option for Excel actually disables the ability for Windows Explorer to launch Excel itself (e.g. by double-clicking on an Excel file). Opening the same file via File -> Open in Excel still works though.

The better mitigation may be to enable ASR features via Windows 10, and still import the "WordMail" registry values above. That is, set D4F940AB-401B-4EFC-AADC-AD5F3C50688A to 1, and import:

Windows Registry Editor Version 5.00

[HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Word\Options\WordMail]
 "DontUpdateLinks"=dword:00000001

[HKEY_CURRENT_USER\Software\Microsoft\Office\15.0\Word\Options\WordMail]
 "DontUpdateLinks"=dword:00000001

[HKEY_CURRENT_USER\Software\Microsoft\Office\14.0\Word\Options\WordMail]
 "DontUpdateLinks"=dword:00000001

NOTE: ASR only works if you are using Windows Defender as your primary AV.

"ASR has a dependency on Windows Defender Antivirus being the primary AV on the device and its real-time protection feature must be enabled."
https://blogs.technet.microsoft.com/mmpc/2017/10/23/windows-defender-exploit-guard-reduce-the-attack-surface-against-next-generation-malware/

thx bro. can you make regitry that works for 2007(version)

I couldn't find discrete, human-readable DDE registry values for Office 2007. For that version of Office, which shouldn't be used for obvious reasons, your best bet is to set the DDE options in the respective Office applications preferences or possibly GPO.
For example, in Word:
Options -> Advanced -> General -> "Update automatic links at open" (uncheck this)
For Excel, the option is called "Ignore other applications that use Dynamic Data Exchange DDE" (but note that this breaks the ability to open Excel files by double-clicking them)

The Outlook attack vector didn't seem to work in my testing with Outlook 2007, so no special protections seem to be needed there.

emmm...if you want enable DDE again:

Windows Registry Editor Version 5.00

[HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Word\Options]
"DontUpdateLinks"=dword:00000000

[HKEY_CURRENT_USER\Software\Microsoft\Office\15.0\Word\Options]
"DontUpdateLinks"=dword:00000000

[HKEY_CURRENT_USER\Software\Microsoft\Office\14.0\Word\Options]
"DontUpdateLinks"=dword:00000000

[HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Word\Options\WordMail]
"DontUpdateLinks"=dword:00000000

[HKEY_CURRENT_USER\Software\Microsoft\Office\15.0\Word\Options\WordMail]
"DontUpdateLinks"=dword:00000000

[HKEY_CURRENT_USER\Software\Microsoft\Office\14.0\Word\Options\WordMail]
"DontUpdateLinks"=dword:00000000

[HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\OneNote\Options]
"DisableEmbeddedFiles"=dword:00000000

[HKEY_CURRENT_USER\Software\Microsoft\Office\15.0\OneNote\Options]
"DisableEmbeddedFiles"=dword:00000000

[HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Excel\Options]
"DontUpdateLinks"=dword:00000000
"DDEAllowed"=dword:00000000
"DDECleaned"=dword:00000000

[HKEY_CURRENT_USER\Software\Microsoft\Office\15.0\Excel\Options]
"DontUpdateLinks"=dword:00000000
"DDEAllowed"=dword:00000000
"DDECleaned"=dword:00000000
"Options"=dword:00000117

[HKEY_CURRENT_USER\Software\Microsoft\Office\14.0\Excel\Options]
"DontUpdateLinks"=dword:00000000
"DDEAllowed"=dword:00000000
"DDECleaned"=dword:00000000
"Options"=dword:00000117

If anyone is curious I tried to do it system-wide by using HKEY_LOCAL_MACHINE but that didn't work to disable the link updates.

Is there any information about what "Options"=dword:00000117 is about?
What, if I already have an Options value other than 00000117? Should it be replaced or should it be added (bitwise?)
Thanks for any hint.